C. elegans as a model system to study development
embryonic development in animals, cells
acquire distinct properties through the activation of
specific genes. This process allows different cell types
to form. We are studying the gene network that
controls specification of
endoderm and mesoderm in the
elegans. Through comparison with related
nematodes, we are examining how this network has undergone
evolutionary change over hundreds of millions
of years. We are also using the endoderm to study stochasticity of early development and the effects of partial specification on metabolism and differentiation in surviving adults.
Prizes have been awarded in C. elegans: 2002 2006 2008
Network Evolution of the Endomesoderm Network
MED-1 structure MED-1,2
and the C.
Stochasticity of Development and Differentiation