C. elegans as a model system to study development

During embryonic development in animals, cells acquire distinct properties through the activation of specific genes. This process allows different cell types to form. We are studying the gene network that controls specification of endoderm and mesoderm in the nematode, C. elegans. Through comparison with related nematodes, we are examining how this network has undergone evolutionary change over hundreds of millions of years. We are also using the endoderm to study stochasticity of early development and the effects of partial specification on metabolism and differentiation in surviving adults.

Three Nobel Prizes have been awarded in C. elegans: 2002 2006 2008

More information: Regulatory Network link to evolution pageEvolution of the Endomesoderm Network
MED-1 structureMED-1 structure MED-1,2 and the C. elegans Endomesoderm
link to evolution pageStochasticity of Development and Differentiation
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Much of the research by the Maduro lab presented on this site
is based upon work supported by the National Science Foundation
under Grant Numbers
IOS#0416922, IOS#0643325, IOS#1258054.